506126
p38 MAP Kinase Inhibitor
The p38 MAP Kinase Inhibitor, also referenced under CAS 219138-24-6, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
p38 MAP Kinase Inhibitor, 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one
登录 查看组织和合同定价。
选择尺寸
关于此项目
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
InChI key
DZFBYHUKZSRPHU-UHFFFAOYSA-N
InChI
1S/C20H13ClFN3O/c21-15-3-7-17(8-4-15)25-20(26)18(13-1-5-16(22)6-2-13)19(24-25)14-9-11-23-12-10-14/h1-12,24H
assay
≥95% (HPLC)
form
solid
potency
35 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A potent p38 MAP kinase inhibitor (IC50 = 35 nM).
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
de Laszlo, S.E., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2689.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
S E de Laszlo et al.
Bioorganic & medicinal chemistry letters, 8(19), 2689-2694 (1999-01-05)
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrol e (L-167307) reduces secondary paw swelling in the rat adjuvant arthritis model: ID50 = 7.4 mg/kg/b.i.d.
Guoqi Zhang et al.
Cancer research, 68(6), 1691-1696 (2008-03-15)
One of the physiologic consequences of excessive UV radiation (UVR) exposure is apoptosis. This critical response serves to eliminate genetically injured cells and arises, in part, from activation of DNA damage and p53 signaling. Other contributory pathways, however, likely exist
Charles B Trelford et al.
Frontiers in cell and developmental biology, 9, 712124-712124 (2021-11-12)
The mechanism(s) in which transforming growth factor beta 1 (TGFβ) modulates autophagy in cancer remain unclear. Here, we characterized the TGFβ signaling pathways that induce autophagy in non-small cell lung cancer cells, using cells lines stably expressing GFP-LC3-RFP-LC3ΔG constructs that
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持