506163
p38 MAP Kinase Inhibitor VIII
The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
p38 MAP Kinase Inhibitor VIII, (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
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About This Item
经验公式（希尔记法）:
C20H16BrClN2O
CAS Number:
分子量:
415.71
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
ethanol: 15 mg/mL
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
Brc1cc(c(cc1)Nc2cc(c(cc2)C(=O)c3c(cccc3)C)Cl)N
InChI
1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
InChI key
HDCLCHNAEZNGNV-UHFFFAOYSA-N
一般描述
A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC′s in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Ottosen, E.R., et al. 2003. J. Med. Chem.46, 5651.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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