5.06236
Tiagabine Hydrochloride
别名:
Tiagabine Hydrochloride, GABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
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经验公式（希尔记法）:
C20H25NO2S2 · xHCl
化学文摘社编号:
分子量:
375.55 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[s]1c(c(cc1)C)C(=CCCN3C[C@@H](CCC3)C(=O)O)c2[s]ccc2C.[Cl-].[H+]
InChI
1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
InChI key
YUKARLAABCGMCN-PKLMIRHRSA-N
assay
≥98% (HPLC)
form
solid
potency
67 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: soluble
Quality Level
General description
A potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
Biochem/physiol Actions
Primary Target
GAT-1
GAT-1
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther.302, 1168.
Hu, Q., et al. 1997. Brain Res.753,260.
Suzdak, P., et al., 1995. Epilepsia.36, 612.
Andersen, E., et al., 1993. J. Med. Chem.36, 1716.
Hu, Q., et al. 1997. Brain Res.753,260.
Suzdak, P., et al., 1995. Epilepsia.36, 612.
Andersen, E., et al., 1993. J. Med. Chem.36, 1716.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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