5.06238
氢溴酸西酞普兰 氢溴酸盐
别名:
1-[3-（二甲氨基）丙基]-1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈 氢溴酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H21FN2O · HBr
化学文摘社编号:
分子量:
405.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
storage temp.
2-8°C
InChI
1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
SMILES string
Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
InChI key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
potency
1.8 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 10 mM, ethanol: 50 mM
Quality Level
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General description
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50 = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.
Biochem/physiol Actions
有效的选择性 5-羟色胺摄取抑制剂 (Ki = 5.4 nM)；抗抑郁药
Primary Target
5-HT Transporter
5-HT Transporter
Preparation Note
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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