5.06238
氢溴酸西酞普兰 氢溴酸盐
别名:
1-[3-（二甲氨基）丙基]-1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈 氢溴酸盐
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About This Item
经验公式（希尔记法）:
C20H21FN2O · HBr
CAS Number:
分子量:
405.30
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
方案
≥98% (HPLC)
质量水平
表单
solid
效能
1.8 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 10 mM
ethanol: 50 mM
储存温度
2-8°C
SMILES字符串
Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
InChI
1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
InChI key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
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一般描述
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50 = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.
生化/生理作用
有效的选择性 5-羟色胺摄取抑制剂 (Ki = 5.4 nM)；抗抑郁药
Primary Target
5-HT Transporter
5-HT Transporter
制备说明
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Harmful (C)
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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