5.06239
Bupropion Hydrochloride
别名:
Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion
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关于此项目
经验公式（希尔记法）:
C13H18ClNO · xHCl
化学文摘社编号:
分子量:
239.74 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Clc1cc(ccc1)C(=O)C(NC(C)(C)C)C.Cl
InChI
1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
InChI key
HEYVINCGKDONRU-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
potency
1.4 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: soluble
Quality Level
General description
A non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.
Biochem/physiol Actions
Primary Target
DAT/NET
DAT/NET
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.
Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.
Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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