5.06272
SB 206553 Hydrochloride
别名:
SB 206553 Hydrochloride, 5-HT 2C Serotonin Receptor Antagonist, SB 206553, 5-HT 2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C17H16N4O · xHCl
化学文摘社编号:
分子量:
292.34 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
SMILES string
[n]1(c2c(cc3c(c2)CCN3C(=O)Nc4cnccc4)cc1)C
InChI
1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
InChI key
QJQORSLQNXDVGE-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
potency
3.2 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: soluble
Quality Level
General description
A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
Biochem/physiol Actions
Primary Target
5-HT2C
5-HT2C
Secondary Target
5-HT2B
5-HT2B
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ros, R. et al. 2013. PNAS.110, 348.
Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持