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Merck
CN

5.06417

Sigma-Aldrich

SB 242084 Hydrochloride

≥98% (HPLC), 5-HT2C receptor antagonist, solid

别名:

SB 242084 Hydrochloride, 5-HT 2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride

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关于此项目

经验公式（希尔记法）:
C21H19ClN4O2 · xHCl
CAS Number:
1260505-34-7
分子量:
394.85 (free base basis)
MDL编号:
MFCD02684417
UNSPSC代码:
12352200
NACRES:
NA.77

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Product Name

SB 242084 Hydrochloride,

方案

≥98% (HPLC)

质量水平

100

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white to pale yellow
pale yellow

溶解性

water: soluble

储存温度

−20°C

SMILES字符串

Clc1cc2c(cc1C)CCN2C(=O)Nc3cnc(cc3)Oc4c(nccc4)C.Cl.Cl

InChI

1S/C21H19ClN4O2.2ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);2*1H

InChI key

GCMNSEILNIPNSX-UHFFFAOYSA-N

相关类别

一般描述

A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.

生化/生理作用

Primary Target
5-HT2C

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111.

Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1.

Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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