5.06419
Methysergide Maleate
别名:
Methysergide Maleate, 5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
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关于此项目
经验公式（希尔记法）:
C21H27N3O2 · xC4H4O4
化学文摘社编号:
分子量:
353.46 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[n]1(c2c3c(c1)C[C@H]4N(C[C@@H](C=C4c3ccc2)C(=O)N[C@H](CO)CC)C)C.OC(=O)\C=C/C(=O)O
InChI
1S/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1
InChI key
LWYXFDXUMVEZKS-ZVFOLQIPSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 10 mM
Quality Level
General description
An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
Biochem/physiol Actions
Primary Target
5-HT
5-HT
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Matsuta, Y. et al. 2013. Exp. Neurol.247, 250.
IUHPAR Database 2013.
Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res.183, 411.
Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther.277, 235.
Colpaert, F. C. et al. 1979. Eur. J. Pharmacol.58, 505.
IUHPAR Database 2013.
Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res.183, 411.
Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther.277, 235.
Colpaert, F. C. et al. 1979. Eur. J. Pharmacol.58, 505.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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