Name: GR 127935 Hydrochloride
Brand: MM

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About This Item

经验公式（希尔记法）:

C₂₉H₃₁N₅O₃ · xHCl

CAS Number:

148642-42-6

分子量:

497.59 (free base basis)

MDL编号:

MFCD08056244

UNSPSC代码:

12352200

NACRES:

NA.77

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方案

≥98% (HPLC)

质量水平

100

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

water: soluble

储存温度

2-8°C

SMILES字符串

Cl.N1(CCN(CC1)c2c(ccc(c2)NC(=O)c3ccc(cc3)c4c(cc(cc4)c5n[o]c(n5)C)C)OC)C

InChI

1S/C29H31N5O3.ClH/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34;/h5-12,17-18H,13-16H2,1-4H3,(H,31,35);1H

InChI key

SRVVUYIJVBLEJI-UHFFFAOYSA-N

一般描述

A selective 5-HT_1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC₅₀ = 97 pM.

生化/生理作用

Primary Target
5-HT_1B/1D

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior.88, 196.

Przegalinski, E. et al. 2008. Pharmacol. Rep.60, 798.
Bannai, M. et al. 2007. Psychopharmacol.93, 295.
McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther.290, 965.

Pauwels, P. J. et al. 1996. J. Neurochem.66, 65.
Skingle, M. et al. 1996. Behav.Brain Res.73, 157.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)