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关于此项目
经验公式(希尔记法):
C50H67N11O11S2
化学文摘社编号:
分子量:
1062.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥95% (HPLC)
Quality Segment
form
solid
potency
0.96 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: soluble
storage temp.
−20°C
SMILES string
S1SCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1(C)C)C(=O)NC(C(O)C)C(=O)N)C(O)C)CCCN)Cc4c5c([nH]c4)cccc5)Cc3ccc(cc3)O)NC(=O)C(N)Cc2ccccc2
InChI
1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
InChI key
PZWWYAHWHHNCHO-UHFFFAOYSA-N
General description
A potent antagonist highly selective for µ opioid receptor (Ki = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.
Biochem/physiol Actions
Primary Target
mu opioid
mu opioid
Physical form
Supplied as trifluoracetate salt
Other Notes
D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)
Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable