5.08148
Nefazodone Hydrochloride
别名:
Nefazodone Hydrochloride, 5-HT 2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
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关于此项目
经验公式（希尔记法）:
C25H32ClN5O2 · xHCl
化学文摘社编号:
分子量:
470.01 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Clc1cc(ccc1)N2CCN(CC2)CCC[n]3nc([n]([c]3=O)CCOc4ccccc4)CC.Cl
InChI
1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
InChI key
DYCKFEBIOUQECE-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
potency
26 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
ethanol: 10 mM, DMSO: 25 mM
Quality Level
General description
A potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
Other Notes
Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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