5.08159
Salvinorin A
别名:
Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A
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关于此项目
经验公式（希尔记法）:
C23H28O8
化学文摘社编号:
分子量:
432.46
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[o]1cc(cc1)[C@H]2OC(=O)[C@H]3[C@@]([C@@H]4[C@]([C@@H](C[C@@H](C4=O)OC(=O)C)C(=O)OC)(CC3)C)(C2)C
InChI
1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
InChI key
OBSYBRPAKCASQB-AGQYDFLVSA-N
assay
≥98% (HPLC)
form
solid
potency
4.3 nM Ki
manufacturer/tradename
Calbiochem®
Quality Level
storage condition
OK to freeze, protect from light
color
white
solubility
ethanol: 10 mM, DMSO: 50 mM
storage temp.
−70°C
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General description
A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (Ki = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (Ki = 5-10 nM). Used in studies of addition.
Biochem/physiol Actions
Primary Target
k opioid receptor
k opioid receptor
Other Notes
Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
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