5.08161
SNC80
别名:
SNC80, δ Opioid Receptor Agonist, SNC80
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关于此项目
经验公式（希尔记法）:
C28H39N3O2
化学文摘社编号:
分子量:
449.63
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
N3([C@H](CN([C@@H](C3)C)CC=C)C)[C@@H](c2cc(ccc2)OC)c1ccc(cc1)C(=O)N(CC)CC
InChI
1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
InChI key
KQWVAUSXZDRQPZ-UMTXDNHDSA-N
assay
≥98% (HPLC)
form
solid
potency
0.32 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
cream
solubility
1 M HCl: 100 mM, DMSO: 20 mM
storage temp.
−20°C
Quality Level
General description
A very potent and selective δ opioid receptor agonist (IC50 = 0.32 µM). Shown to induce dose- and time-dependent antinociception after i.c.v., i.th. and i.p. administration in mice. Widely used in studies of depression and inflammatory injuries. It is also reported to be acted upon heteromeric u-d receptors.
Biochem/physiol Actions
Primary Target
Dela opioid receptor
Dela opioid receptor
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pradhan, A., et al., 2013. Mol Pain.9, 8.
Saitoh, A., et al., 2012. Curr. Neuropharmacol.10, 231.
Metcalf. M. et al. 2012. ACS Chem. Neurosci.3, 505.
Bilsky, J., et al. 1995. J. Pharmacol. Exp. Ther.273, 359.
Saitoh, A., et al., 2012. Curr. Neuropharmacol.10, 231.
Metcalf. M. et al. 2012. ACS Chem. Neurosci.3, 505.
Bilsky, J., et al. 1995. J. Pharmacol. Exp. Ther.273, 359.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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