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5.08227

Paclitaxel

InSolution, ≥97%, 25 mM in DMSO, from Taxus sp.

别名:

InSolution 紫杉醇，红豆杉, 紫杉醇®溶液，浆果赤霉素III N-苄基-β-苯基异丝氨酸酯

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关于此项目

经验公式（希尔记法）:
C47H51NO14
化学文摘社编号:
33069-62-4
分子量:
853.91
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00869953
Assay:
≥97% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
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产品名称

紫杉醇，来源于红豆杉, InSolution, ≥97%, 25 mM in DMSO

Quality Segment

100

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

N([C@H]([C@@H](O)C(=O)O[C@H]3C[C@]4([C@H](C6[C@]7([C@H](OC7)C[C@@H]([C@]6(C(=O)[C@@H](C(=C3C)C4(C)C)OC(=O)C)C)O)OC(=O)C)OC(=O)c5ccccc5)O)c2ccccc2)C(=O)c1ccccc1

InChI

1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1

InChI key

RCINICONZNJXQF-VAZQATRQSA-N

General description

Paclitaxel, a microtubule-stabilizing agent, is a tricyclic diterpenoid characterized by a “taxane” complex ring and an amide group, which sometimes leads to its classification as a pseudo alkaloid. Its mechanism of action involves selectively disrupting microtubule dynamics, resulting in mitotic arrest and subsequent cell death. Paclitaxel demonstrates antineoplastic properties with a wide range of antitumor activity. As a chemotherapeutic agent, it selectively binds to the β-subunit of tubulin proteins, facilitating their polymerization and assembly, which stabilizes microtubule formation. This stabilization creates a dysfunctional mitotic spindle, leading to significant mitotic arrest during the G2/M phase and ultimately causing cell death via an apoptosis pathway.

Application

Paclitaxel has been used to study fibronectin type III domain-containing protein 5 (FNDC5)-mediated paclitaxel sensitivity in non-small cell lung cancer (NSCLC) cells.

Biochem/physiol Actions

可逆性：是
细胞可渗透性：具有

Packaging

用惰性气体包装

Physical form

红豆杉属来源紫杉醇固体（货号580555）的DMSO无菌过滤溶液，浓度O.25 mM (10 mg/468 µL)。

Other Notes

Derry, W.B., et al. 1995.Biochemistry34, 2203.
Milas, L., et al. 1995.Cancer Chemother.Pharmacol.35, 297.
Donaldson, K.L., et al. 1994.Int. J. Cancer57, 847.
Hornback, N.B., et al. 1994.In Vivo8, 819.
Manthey, C.L., et al. 1992.J. Immunol.149, 2459.
Rowinsky, E.K., et al. 1992.Semin.Oncol.19, 646.
Ding, A.H., et al. 1990.Science248, 370.
Mogensen, M.M. and Tucker, J.B.1990.J. Cell Sci.97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D.1990.J. Clin. Pharmacol.30, 770.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Taxol is a registered trademark of Bristol-Myers Squibb Co.

Disclaimer

毒性：标准处理（A）

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 2 - Repr. 1B - STOT RE 2

wgk

WGK 2

flash_point_f

188.6 °F

flash_point_c

87 °C

target_organs

Central nervous system,Bone marrow,Cardio-vascular system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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