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5.08316

CTAP

Name: CTAP
Brand: MM

别名:

CTAP, µ opioid receptor antagonist, CTAP

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关于此项目

经验公式（希尔记法）:

C₅₁H₆₉N₁₃O₁₁S₂

化学文摘社编号:

103429-32-9

分子量:

1104.30

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00671434

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

assay

≥95% (HPLC)

Quality Level

100

form

solid

potency

3.5 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

water: soluble

storage temp.

−20°C

SMILES string

S1SC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C1(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)N)[C@H](O)C)CCCN=C(N)N)Cc4c5c([nH]c4)cccc5)Cc3ccc(cc3)O)NC(=O)[C@H](N)Cc2ccccc2

InChI

1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

InChI key

OFMQLVRLOGHAJI-FGHAYEPSSA-N

说明

General description

A highly potent octapeptide that acts as a selective and brain penetrating bioavailable µ opioid receptor antagonist (IC₅₀ = 3.5 nM). Used in studies of reward systems and additions.

Biochem/physiol Actions

Primary Target
u Opioid receptpr

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (2-7 disulfide bond)

Perry, C., et al., 2013. Behav. Neurosci.127, 535.
Burkett, J. et al. 2011. Neuropsychopharm.36, 2200.
Steinmiller, L., et al., 2008. Psychopharmacol. (Berl).195, 497.
Sterious, S., et al., 2003. J. Pharmacol. Exp. Ther.304, 301.
Abbruscato, T., et al. 1997. J. Pharmacol.280, 402.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c