A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10 µM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300 mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.

Cell permeable: yes

Primary Target
SHIP2

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Ichihara, Y., et al, 2013. Eur. J. Med. Chem.62, 649.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)