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Merck
CN

5.08437

Pepstatin A

≥98% (HPLC), aspartic proteases inhibitor, liquid

别名:

InSolution Pepstatin A, Synthetic, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid, Pepstatin A, Synthetic InSolution, Pepstatin A, Synthetic InSolution, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

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关于此项目

经验公式（希尔记法）:
C34H63N5O9
化学文摘社编号:
26305-03-3
分子量:
685.89
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00060740

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产品名称

Pepstatin A, InSolution, ≥98%, Synthetic, protease inhibitor

SMILES string

N([C@@H](C(C)C)C(=O)NC(C(O)CC(=O)N[C@@H](C)C(=O)NC(C(O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)CC(C)C)C(C)C

InChI

1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1

InChI key

FAXGPCHRFPCXOO-JHTFMCFMSA-N

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

storage temp.

−70°C

相关类别

Disclaimer

Toxicity: Standard Handling (A)

Other Notes

Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.

Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.
Iva-Val-Val-Sta-Ala-Sta

Packaging

Packaged under inert gas

Physical form

A 25 mM (10 mg/583 µL) sterile-filtered solution of Pepstatin A, Synthetic (Cat. No. 516481-M) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 4 months at -20°C. Use only fresh DMSO for further dilutions.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Features and Benefits

  • Primary Target: aspartic proteases
  • Reversible: yes

General description

Pepstatin A, a pentapeptide containing two non-proteinogenic statin residues, is a highly effective inhibitor of cathepsin D (CTSD). It also inhibits other aspartic proteases at nanomolar concentrations (with a Ki of 10-10 M). Pepstatin A is commonly utilized for mapping, purifying, or titrating CTSD. Pepstatin A is found to block the invasion of C. albicans into corneocytes in mice with cutaneous candidiasis and inhibit aspartyl proteases.

Application

Pepstatin A has been used as a negative control in enzymatic activity assays to inhibit CTSD activity in lysosomal studies involving chondrocytes.

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

法规信息

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