5.08506
Gabapentin
别名:
Gabapentin, L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
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关于此项目
经验公式（希尔记法）:
C9H17NO2
化学文摘社编号:
分子量:
171.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[N+H3]CC1(CCCCC1)CC(=O)[O-]
InChI
1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
InChI key
UGJMXCAKCUNAIE-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 100 mM
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Primary Target
α2δ subunit of L-type voltage gated Ca2+ channels
α2δ subunit of L-type voltage gated Ca2+ channels
Disclaimer
Toxicity: Standard Handling (A)
General description
A water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.
Other Notes
Eroglu, C. et al. 2009. Cell.139, 380.
Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628.
Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628.
Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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