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5.08514

Psalmotoxin-1

Name: Psalmotoxin-1
Brand: MM

别名:

Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1

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关于此项目

经验公式（希尔记法）:

C₂₀₀H₃₁₂N₆₂O₅₇S₆

化学文摘社编号:

316808-68-1

分子量:

4689.39

MDL number:

MFCD00004691

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥94% (HPLC)

Form:

semisolid, viscous liquid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

assay

≥94% (HPLC)

Quality Level

100

form

semisolid, viscous liquid

potency

0.9 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

colorless

storage temp.

−20°C

说明

General description

A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC₅₀ = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.

Biochem/physiol Actions

Primary Target
ASIC1a

Other Notes

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)

Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c