5.08514
Psalmotoxin-1
别名:
Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1
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关于此项目
经验公式（希尔记法）:
C200H312N62O57S6
化学文摘社编号:
分子量:
4689.39
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥94% (HPLC)
form
semisolid, viscous liquid
potency
0.9 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
colorless
storage temp.
−20°C
Quality Level
General description
A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
Biochem/physiol Actions
Primary Target
ASIC1a
ASIC1a
Other Notes
EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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