5.09705
L-Serine-O-phosphate
别名:
L-Serine-O-phosphate, L-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-SOP, L-Serine O-phosphate
InChI
1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChI key
BZQFBWGGLXLEPQ-REOHCLBHSA-N
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 50 mg/mL
storage temp.
10-30°C
Quality Level
General description
A potent agonist for group III mGlu receptor subtype 4, 6, and 8 (EC50 = 1-4, 3, and 2 µM for mGlu4, mGlu6, mGlu8, respectively); but not for subtype 7 (EC50 = 160-1200 µM). Inhibits proliferation and enhances neuronal differentiation in progenitor cells. Widely used to study presynaptic inhibitory modulation of the excitatory glutamatergic transmission at retina and central nervous systems.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
mGlu₄, mGlu₆, mGlu₈
mGlu₄, mGlu₆, mGlu₈
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Eriksen, L., et al. 1995. Br. J. Pharmacol.116, 3279.
Thoreson, W., et al. 1995. Brain Res.676, 93.
Bruno, V., et al. 1996. Eur. J. Pharmacol.310, 61.
Saxe, J., et al. 2007. Chem. Biol.14, 1019.
Nakajima, Y., 1993. J. Biol. Chem.268, 11868.
Thoreson, W., et al. 1995. Brain Res.676, 93.
Bruno, V., et al. 1996. Eur. J. Pharmacol.310, 61.
Saxe, J., et al. 2007. Chem. Biol.14, 1019.
Nakajima, Y., 1993. J. Biol. Chem.268, 11868.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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