511075
血小板活化因子-16
≥98% (TLC), lyophilized solid, inflammation mediator, Calbiochem®
别名:
血小板活化因子-16, PAF（C₁₆），1-O-棕榈酰基-2-乙酰基-sn-甘油-3-磷酸胆碱，1-O-十六烷基-2-乙酰基-sn-甘油-3-磷酸胆碱
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关于此项目
经验公式（希尔记法）:
C26H54NO7P
化学文摘社编号:
分子量:
523.68
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.77
产品名称
血小板活化因子-16, A potent mediator of inflammation that increases vascular permeability. Activates MAP kinases and MAP kinase kinase (MEK) in CHO cells.
SMILES string
[P](=O)([O-])(OC[C@H](OC(=O)C)COCCCCCCCCCCCCCCCC)OCC[N+](C)(C)C
InChI
1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
InChI key
HVAUUPRFYPCOCA-AREMUKBSSA-N
assay
≥98% (TLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white to off-white
solubility
ethanol: 0.5-1 mg/mL, water: soluble
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
General description
合成。一种增强血管通透性的有效炎症介质。激活CHO细胞中的MAP激酶和MAP激酶激酶（MEK）。
合成水溶性血小板活化因子。一种增强血管通透性的有效炎症介质。激活CHO细胞中的MAP激酶和MAP激酶激酶（MEK）。
Biochem/physiol Actions
主要靶标
MAP激酶和MAP激酶激酶（MEK）
MAP激酶和MAP激酶激酶（MEK）
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
复溶后，等分并在惰性气体下冷冻（-20°C 或 -70°C）保存。贮备水溶液在-20°C可稳定保存长达3天。乙醇贮备液在-70°C可稳定保存长达3个月。
Other Notes
Honda, Z., et al. 1994.J. Biol. Chem. 269, 2307.
Mori, M., et al. 1994.Ann.N.Y.Acad.Sci.744, 107.
Pinckard, R.N., et al. 1992.J. Immunol.148, 3528.
Salari, H., et al. 1992.Biochem.Cell Biol.70, 129.
Mori, M., et al. 1994.Ann.N.Y.Acad.Sci.744, 107.
Pinckard, R.N., et al. 1992.J. Immunol.148, 3528.
Salari, H., et al. 1992.Biochem.Cell Biol.70, 129.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
R H Adamson et al.
American journal of physiology. Heart and circulatory physiology, 285(1), H406-H417 (2003-03-22)
We tested the hypothesis that acutely induced hyperpermeability is dependent on actin-myosin contractility by using individually perfused mesentery venules of pentobarbital-anesthetized rats. Venule hydraulic conductivity (Lp) was measured to monitor hyperpermeability response to the platelet-activating factor (PAF) 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine or bradykinin.
Emily A Henderson et al.
Frontiers in immunology, 15, 1363962-1363962 (2024-03-22)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer associated with an immunosuppressive environment. Neutrophil extracellular traps (NETs) were initially described in the context of infection but have more recently been implicated in contributing to the tolerogenic immune response in PDAC.
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