520219
PPACK II trifluoroacetate salt
≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem®
别名:
PPACK II，三氟醋酸盐
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关于此项目
经验公式（希尔记法）:
C25H33ClN6O3 · 2C2HF3O2
化学文摘社编号:
分子量:
729.07
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated
产品名称
PPACK II，三氟醋酸盐, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
off-white
solubility
water: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
ClCC(=O)[C@@H](N[C@@H](Cc2ccccc2)C(=O)NC(=O)[C@H](N)Cc1ccccc1)CCCNC(=N)N
InChI
1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1
InChI key
UFXAQJOOAQICNE-HKBOAZHASA-N
General description
血浆和腺体激肽释放酶的强效和特异性不可逆抑制剂。抑制激肽释放酶对心房钠尿肽（ANP 1-126）的裂解。也抑制肾上腺激肽原酶 （一种激肽释放酶样酶）。也可以提供10 mM的DMSO溶液。
Biochem/physiol Actions
主要靶标
血浆和腺体激肽释放酶
血浆和腺体激肽释放酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多2个月。
Other Notes
Byrne, R.E., and Scanu, A.M. 1989.J. Lipid Res. 30, 109.
Scicli, G., et al. 1989.Adv.Exp.Med. Biol.247B, 217.
Gibson, T.R., et al. 1987.Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981.Methods Enzymol.80, 826.
Scicli, G., et al. 1989.Adv.Exp.Med. Biol.247B, 217.
Gibson, T.R., et al. 1987.Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981.Methods Enzymol.80, 826.
H-D-Phe-Phe-Arg-氯甲基酮，2TFA
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
怎么回事？
WGK 2
闪点 (F)
Not applicable
闪点 (°C)
Not applicable