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Merck
CN

524394

4α-Phorbol 12,13-didecanoate

>99% (HPLC), solid, PDD and PMA negative control, Calbiochem®

别名:

4α-Phorbol-12,13-didecanoate, 4αPDD, PKC Activator I, Negative Control

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关于此项目

经验公式（希尔记法）:
C40H64O8
化学文摘社编号:
27536-56-7
分子量:
672.93
UNSPSC Code:
12352211
NACRES:
NA.77
MDL number:
MFCD00036737
Assay:
>99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze

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产品名称

4α-Phorbol-12,13-didecanoate, Inactive on mouse skin as an inflammatory and tumor-promoting agent.

SMILES string

O([C@]21[C@H]([C@H]3[C@@]([C@H]4[C@@](CC(=C3)CO)(C(=O)C(=C4)C)O)([C@@H]([C@H]2OC(=O)CCCCCCCCC)C)O)C1(C)C)C(=O)CCCCCCCCC

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI key

DGOSGFYDFDYMCW-OEFRVDPMSA-N

assay

>99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: soluble, ethanol: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
A negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA)
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Highly Toxic (H)

General description

Inactive on mouse skin as an inflammatory and tumor-promoting agent. Useful as a negative control for Phorbol-12,13-didecanoate (PDD; Cat. No. 524392) and Phorbol-12-myristate-13-acetate (PMA; Cat. No. 524400).
Reported to be inactive on mouse skin as an inflammatory and tumor-promoting agent. Used as a negative control for phorbol-12,13-didecanoate (PDD, Cat. No. 524392) and phorbol-12-myristate-13-acetate (PMA, Cat. No. 524400).

Other Notes

Akiguchi, I., et al. 1993. Endocrinology 138, 379.
Clarke, B.L., et al. 1993. Endocrinology132, 1168.
Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med.121, 337.
Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol.43, 223.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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