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Merck
CN

524403

Sigma-Aldrich

Pravastatin, Sodium Salt

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).

别名:

(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na, Pravastatin, Sodium Salt

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关于此项目

线性分子式:
C23H35O7.Na
化学文摘社编号:
81131-70-6
MDL编号:
MFCD09843380
UNSPSC代码:
12352200
NACRES:
NA.77

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质量水平

100

描述

Merck USA index - 14, 7714

方案

≥98% (HPLC)

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 100 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[Na+].[O-]C(=O)C[C@H](O)C[C@H](O)CC[C@@H]1[C@H]2[C@H](C[C@@H](C=C2C=C[C@@H]1C)O)OC(=O)[C@H](CC)C

InChI

1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1

InChI key

VWBQYTRBTXKKOG-IYNICTALSA-M

相关类别

一般描述

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.

生化/生理作用

Cell permeable: no
Primary Target
AMG-CoA reductase
Product does not compete with ATP.
Reversible: no
Target Ki: ~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kwak, B., et al. 2000. Natl. Med.6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci.19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res.87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol.45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta.1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Environmental Hazard (N)

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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