526521
PIM1 Inhibitor III
The PIM1 Inhibitor III controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
PIM1 Inhibitor III
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
purple
solubility
DMSO: 6 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
Biochem/physiol Actions
Cell permeable: no
Primary Target
PIM1
PIM1
Product does not compete with ATP.
Reversible: no
Target IC50: 0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Bergman, H. and Meggers, E., 2006. Org. Lett.8, 5465.
Legal Information
Sold for research purposes only, pursuant to an agreement with University of Pennsylvania.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Howard Bregman et al.
Organic letters, 8(24), 5465-5468 (2006-11-17)
Cyclopentadienyl half-sandwich ruthenium complexes have been demonstrated to be promising scaffolds as protein kinase inhibitors. In order to rapidly identify derivatives which display modified pharmacological properties, we developed the synthesis of an organoruthenium compound bearing an N-succinimidyl ester at the
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