527455
PKR Inhibitor, Negative Control
The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
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关于此项目
经验公式（希尔记法）:
C15H8Cl3NO2
化学文摘社编号:
分子量:
340.59
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
Clc1c(c(cc(c1)C=C2c3c(ccc(c3)Cl)NC2=O)Cl)O
InChI
1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)
InChI key
ZJFMARHFPUZEKI-UHFFFAOYSA-N
assay
≥95% (sum of two isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL, ethanol: 10 mg/mL
shipped in
ambient
Quality Level
General description
An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50 >100 µM) or in rescuing PKR-dependent translation block.
Biochem/physiol Actions
Cell permeable: no
Primary Target
A negative control for PKR Inhibitor
A negative control for PKR Inhibitor
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
Sanket S Ponia et al.
Cell reports, 37(4), 109888-109888 (2021-10-28)
Dysregulated inflammation dominated by chemokine expression is a key feature of disease following infection with the globally important human pathogens Zika virus (ZIKV) and dengue virus, but a mechanistic understanding of how pro-inflammatory responses are initiated is lacking. Mitophagy is
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