528118
PI 3-Kδ抑制剂X，IC87114
The PI 3-Kδ Inhibitor X, IC87114, also referenced under CAS 371242-69-2, controls the biological activity of PI 3-Kδ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
PI 3-Kδ抑制剂X，IC87114, 磷脂酰肌醇3-激酶p110d抑制剂，PI 3-K抑制剂X
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选择尺寸
关于此项目
经验公式（希尔记法）:
C22H19N7O
化学文摘社编号:
分子量:
397.43
NACRES:
NA.77
MDL number:
UNSPSC Code:
12352200
SMILES string
[n]4(c5ncnc(c5nc4)N)Cc1[n]([c](c3c(n1)cccc3C)=O)c2c(cccc2)C
InChI
1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)
InChI key
GNWHRHGTIBRNSM-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
在NB-4和原代APL细胞中的PI 3-Kδ的细胞可渗透选择性抑制剂（p110b，p110d和p110g的IC50分别为1.82、0.07和1.24，但也可能以100 µM高浓度靶向p110a，但效价较低）。据报告，原发性AML细胞中PI3K/Akt信号传导的组成性激活主要归因于PI 3-Kδ。已显示PI 3-Kδ抑制剂的药理用途可阻断PI3K/Akt/mTOR信号传导，从而可减少增殖并诱导凋亡。一项相关研究进一步表明，PI 3-Kδ抑制剂是过敏和肥大细胞相关疾病的PI 3-K亚型中的关键治疗靶点。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Billottet, C., et al. 2009.Cancer Res.69,1027.
Ali, K., et al. 2008.J. Immunol.180, 2538.
Ali, K., et al. 2008.J. Immunol.180, 2538.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Yukai Jing et al.
Science advances, 6(17), eaax9455-eaax9455 (2020-06-05)
The adaptor protein, STING (stimulator of interferon genes), has been rarely studied in adaptive immunity. We used Sting KO mice and a patient's mutated STING cells to study the effect of STING deficiency on B cell development, differentiation, and BCR
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