528825
PARP Inhibitor XV, UPF-1035
The PARP Inhibitor XV, UPF-1035, also referenced under CAS 370872-09-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
PARP Inhibitor XV, UPF-1035, 5-Benzoyloxyisoquinolin-1(2H)-one
InChI key
FFWUPFYTTMMSTH-UHFFFAOYSA-N
InChI
1S/C16H11NO3/c18-15-13-7-4-8-14(12(13)9-10-17-15)20-16(19)11-5-2-1-3-6-11/h1-10H,(H,17,18)
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale beige
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable isoquinolinone compound that acts as an NAD+-binding site-targeting, PARP-2-selective inhibitor (IC50 against murine PARP-2 and bovine PARP-1 = 0.15 and 8.0 µM, respectively). Reported to preferentially inhibit PARP activity in nuclear extracts derived from PARP-1-/- over PARP-1+/+ murine fibroblasts (by 80% and 15%, respectively, at 10 µM), while exhibiting little effect against tankyrase-1-dependent mitotic spindle formation in HeLa cells even at concentrations as high as 100 µM.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Moroni, F., et al. 2009. Br. J. Pharmacol.157, 854.
Pellicciari, R., et al. 2008. ChemMedChem3, 914.
Pellicciari, R., et al. 2008. ChemMedChem3, 914.
Soluble in DMSO ( mg/ml), aliquot & store at -20*C; stable for 6 months.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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