5291
硫酸多粘菌素 B
Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.
别名:
硫酸多粘菌素 B
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关于此项目
Form:
solid
Storage condition:
OK to freeze
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
water: 25 mg/mL
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
General description
多粘菌素B是一种多肽抗菌药物，属于多粘菌素家族。对革兰氏阴性菌均有抑制作用，例如铜绿假单胞菌、鲍曼不动杆菌、肠杆菌、克雷伯氏菌。硫酸多粘菌素B是硫酸多粘菌素B1和硫酸多粘菌素 B2的混合物。
Application
硫酸多粘菌素B - CAS 1405-20-5 – Calbiochem已用于：
- 中和牛血清白蛋白中的内毒素
- 肝星状细胞(HSC)的体外治疗
- 作为抗生素用于大肠杆菌侧支敏感和交叉耐药分析
Biochem/physiol Actions
多粘菌素B具有抗内毒素活性。它与脂多糖(LPS)分子的脂质A结合，通过置换革兰氏阴性菌外膜的Ca2+和Mg2+促进渗透。
Other Notes
Lucas, M., et al. 1994.生物化学。Pharmacol.47, 667.
Ngezahayo, A. and Kolb, H.A.1993.Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992.J. Physiol.456, 351.
Strasser, S.H., et al. 1992.Circ.Res.70, 1304.
Hegemann, L., et al. 1991.Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991.Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990.J. Immunol.144, 662.
Ngezahayo, A. and Kolb, H.A.1993.Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992.J. Physiol.456, 351.
Strasser, S.H., et al. 1992.Circ.Res.70, 1304.
Hegemann, L., et al. 1991.Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991.Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990.J. Immunol.144, 662.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable