硫酸多粘菌素 B

Name: 硫酸多粘菌素 B
Brand: MM

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca²⁺-dependent protein kinases.

别名:

硫酸多粘菌素 B

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化学文摘社编号:

1405-20-5

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD00131991

主要文件

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产品名称

硫酸多粘菌素 B, Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca²⁺-dependent protein kinases.

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white to off-white

solubility

water: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

200

Application

硫酸多粘菌素B - CAS 1405-20-5 – Calbiochem已用于：

中和牛血清白蛋白中的内毒素
肝星状细胞(HSC)的体外治疗
作为抗生素用于大肠杆菌侧支敏感和交叉耐药分析

Biochem/physiol Actions

多粘菌素B具有抗内毒素活性。它与脂多糖(LPS)分子的脂质A结合，通过置换革兰氏阴性菌外膜的Ca²⁺和Mg²⁺促进渗透。

Disclaimer

毒性：有害（C）

General description

多粘菌素B是一种多肽抗菌药物，属于多粘菌素家族。对革兰氏阴性菌均有抑制作用，例如铜绿假单胞菌、鲍曼不动杆菌、肠杆菌、克雷伯氏菌。硫酸多粘菌素B是硫酸多粘菌素B₁和硫酸多粘菌素 B₂的混合物。

Other Notes

Lucas, M., et al. 1994.生物化学。Pharmacol.47, 667.
Ngezahayo, A. and Kolb, H.A.1993.Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992.J. Physiol.456, 351.
Strasser, S.H., et al. 1992.Circ.Res.70, 1304.
Hegemann, L., et al. 1991.Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991.Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990.J. Immunol.144, 662.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Aggregation can be selectively induced by aggregation-prone regions (APRs) contained in the target proteins. Aggregation-inducing antimicrobial peptides (Pept-ins) contain sequences homologous to APRs of target proteins and exert their bactericidal effect by causing aggregation of a large number of proteins.

Andrea Kwa et al.

Expert review of anti-infective therapy, 5(5), 811-821 (2007-10-05)

Hospital-acquired infections due to multidrug-resistant gram-negative bacteria constitute major health problems, since the medical community is continuously running out of available effective antibiotics and no new agents are in the pipeline. Polymyxins, a group of antibacterials that were discovered during

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Tetrahydroxy stilbene glucoside (TSG) has been reported to exert a cytoprotective effect against various toxicants. However, the function and mechanism of TSG in palmitic acid (PA)-induced inflammation and apoptosis in cardiomyocytes are still unknown. The present study was designed to

Associations between sensitivity to antibiotics, disinfectants and heavy metals in natural, clinical and laboratory isolates of Escherichia coli.

Anna M Bischofberger et al.

Environmental microbiology, 22(7), 2664-2679 (2020-03-13)

Bacteria in nature often encounter non-antibiotic antibacterials (NAAs), such as disinfectants and heavy metals, and they can evolve resistance via mechanisms that are also involved in antibiotic resistance. Understanding whether susceptibility to different types of antibacterials is non-randomly associated across

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硫酸多粘菌素 B

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

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主要文件

属性

产品名称

InChI

InChI key

form

manufacturer/tradename

storage condition

color

solubility

shipped in

storage temp.

Quality Level

说明

Application

Biochem/physiol Actions

Disclaimer

General description

Other Notes

Legal Information

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca²⁺-dependent protein kinases.