529505
PON1 Activator, ZNPA
The PON1 Activator, ZNPA modulates the biological activity of PON1. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
PON1 Activator, ZNPA, (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile
质量水平
方案
≥99% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
DMSO: 25 mg/mL, pale yellow
运输
ambient
储存温度
−20°C
SMILES字符串
N#C/C(C1=CC=C(C=C1)[N+]([O-])=O)=C\C2=CC=C(C=C2)[N+]([O-])=O
InChI
1S/C15H9N3O4/c16-10-13(12-3-7-15(8-4-12)18(21)22)9-11-1-5-14(6-2-11)17(19)20/h1-9H/b13-9+
InChI key
QPMLLJYCAKQATA-UKTHLTGXSA-N
一般描述
A cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50 = 1 µM) and inducer of PON1 enzymatic activity (>3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Guyot, E., et al. 2011. Biochem. Pharm. 83, 627.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持