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529573

PP2

≥95% (HPLC), solid, Src protein tyrosine kinase inhibitor, Calbiochem®

别名:

PP2

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关于此项目

经验公式（希尔记法）:
C15H16ClN5
化学文摘社编号:
172889-27-9
分子量:
301.77
MDL number:
MFCD01568210
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
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产品名称

PP2, PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC50 = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)c2n[n](c3ncnc(c32)N)C(C)(C)C

InChI

1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)

InChI key

PBBRWFOVCUAONR-UHFFFAOYSA-N

General description

蛋白酪氨酸激酶Src家族的一种有效、可逆、ATP竞争性和选择性抑制剂。抑制p56lck （IC50=4 nM），p59fynT（IC50=5 nM），Hck（IC50=5 nM）和Src（IC50=100 nM）。不会显著影响EGFR激酶（IC50=480 nM），JAK2（IC50 >50 µM）或ZAP-70（IC50 >100 µ M）的活性。抑制黏着斑激酶的活化及其在Tyr577位点的磷酸化。还有效抑制人T细胞的抗CD3刺激的酪氨酸磷酸化（IC50=600 nM）。也可购买10 mM（1 mg/331 µl）PP2 （目录号529576）DMSO溶液。

Biochem/physiol Actions

主要靶标
p56lck
产物与ATP竞争。
可逆性：是
细胞渗透性：否
靶标IC50：针对p56lck，p59fynT，Hck和Src分别为4 nM，5 nM，5 nM，100 nM；人T细胞的CD3刺激的酪氨酸磷酸化为600 nM

Packaging

用惰性气体包装

Preparation Note

仅在使用前再用水相缓冲液进行稀释。

Other Notes

Karni, R., et al. 2003.FEBS Lett.537, 47.
Salazar, E.P., and Rozengurt, E. 1999.J. Biol. Chem. 274, 28371.
Hanke, J.H., et al. 1996.J. Biol. Chem.271, 695.



Selected Citations
Lee, J., et al. 2009.Cell Stem Cell5, 76.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

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存储类别

11 - Combustible Solids

wgk

WGK 3

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全球贸易项目编号

货号GTIN
529573-5MG04055977269802
529573-1MG07790788051198