529605-M
PP1类似物
InSolution, ≥97%, ATP-competitive, inhibitor of Src-family tyrosine kinases
别名:
InSolution PP1 类似物
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Assay:
≥97% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
assay
≥97% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
storage temp.
−70°C
InChI
1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
InChI key
XSHQBIXMLULFEV-UHFFFAOYSA-N
General description
Src家族酪氨酸激酶的强效，可逆，ATP竞争性和细胞可渗透抑制剂，与野生型v-Src（IC50=1.0 µnM）相比，对I338G突变体v-Src（IC50 = 1.5 nM）的选择性高>800倍。也抑制野生型Fyn（IC50=600 nM）。10 mM（1 mg/315 µl）PP1类似物（目录号529579）的DMSO溶液。
Physical form
10 mM（1 mg/315 µl）PP1类似物（目录号529579）的DMSO溶液。
Preparation Note
初次解冻后，分装冻存（-70°C）。
Other Notes
Bishop, A.C., et al. 2000.Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.
Legal Information
不可在美国销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)