529627
PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem
The PPIase-Parvulin Inhibitor, also referenced under CAS 64005-90-9, controls the biological activity of PPIase-Parvulin.
别名:
PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem, PiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
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关于此项目
Quality Segment
assay
≥95% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
brownish
solubility
chloroform: 1 mg/mL, ethanol: 250 μg/mL, cloudy (suspension)
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C22H18N2O8/c1-3-31-15(25)9-23-19(27)11-5-7-13-18-14(8-6-12(17(11)18)20(23)28)22(30)24(21(13)29)10-16(26)32-4-2/h5-8H,3-4,9-10H2,1-2H3
InChI key
WNKQGFNIIHNGQM-UHFFFAOYSA-N
General description
A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties (IC50<5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity (IC50 = ~ 1.5 µM). Does not bind to DNA or functions as a topoisomerase I inhibitor.
A cell-permeable, napthalenetetracarboxylic-bismide compound that displays anti-proliferative properties (IC50<5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site-binding inhibitor of Pin1/Par14 peptidylprolyl cis-trans isomerase (PPIase) activity (IC50 ~ 1.5 µM). Does not bind to DNA or function as a topoisomerase I inhibitor.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
Product competes with ATP.
Reversible: yes
Target IC50: <5 µM for anti-proliferative properties against a panel of human cancer cell lines; ~ 1.5 µM inhibiting Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Uchida, T., et al. 2003. Chem. Biol.10, 15.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13