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Merck
CN

5.30538

Pyrrophenone

≥98% (HPLC), cPLA2α Inhibitor II, powder

别名:

cPLA2α Inhibitor II, Pyrrophenone, Phospholipase A2α Inhibitor

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关于此项目

经验公式（希尔记法）:
C49H37F2N3O5S2
化学文摘社编号:
341973-06-6
分子量:
849.96
MDL number:
MFCD00009107
UNSPSC Code:
12352200
NACRES:
NA.77

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产品名称

cPLA2α Inhibitor II, Pyrrophenone,

assay

≥98% (HPLC)

form

powder

potency

4.2 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 100 mg/mL

storage temp.

−20°C

Quality Level

100

相关类别

General description

Pyrrophenone is a cell-permeable, non-toxic, pyrolidine derivative that acts as a highly potent, and reversible inhibitor of cytosolic phospholipase A2a (cPLA2a; IC50 = 4.2 nM). Does not inhibit the activities of PLA IB and IIA groups even at higher concentrations (~250 µM). Unlike AACOCF3 (Cat. No. 100109), its action is shown to be rapid and does not require a pre-incubation period. Diminishes the release of arachidonic acid (IC50 = 24 nM), prostaglandin E2 (PGE2; IC50 = 25 nM) and leukotriene C4 (IC50 = 14 nM) in A23187 stimulated THP-1 cells. Its effects on production of PGE2 and thromboxane B2 are comparable to those of indomethacin. Also shown to inhibit the lysophospholipase and esterase activity of cPLA2&alpha.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PLA2a

Packaging

Packaged under inert gas

Other Notes

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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