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5.30748

SRT1720 HCl

Name: SRT1720 HCl
Brand: MM

InSolution, ≥98%, 25 mM in DMSO

别名:

InSolution SRT1720, HCl, N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, 4HCl;, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SRT1720, HCl InSolution, HAT Inhibitor XI, SIRT3 Inhibitor II, Sirtuin-3 In

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关于此项目

经验公式（希尔记法）:

C₂₅H₂₃N₇OS · xHCl

MDL number:

MFCD18074509

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

[s]1c2[n](c(c1)CN6CCNCC6)cc(n2)c3c(cccc3)NC(=O)c4nc5c(nc4)cccc5.Cl

InChI

1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H

InChI key

DTGRRMPPXCRRIM-UHFFFAOYSA-N

General description

An enhanced aqueous soluble version of SRT1720 (Cat. No. 567860 ).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
SIRT3

Reversible: yes

Secondary Target
p300 HAT

Packaging

Packaged under inert gas

Physical form

A 25 mM (10 mg/650 µl) sterile-filtered solution of SRT1720, HCl (Cat. No. 567860 ) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Baur, J.A., et al. 2012. Nat. Rev. Drug Discov.11, 443.
Minor, R.K., et al. 2011. Sci. Rep.1, 70.

Huber, J.L., et al. 2010. Future Med. Chem.2, 1751.
Pacholec, M., et al. 2010. J. Biol. Chem.285, 8340.
Jin, L., et al. 2009. Protein Sci.18, 514.
Feige, J.N., et al. 2008. Cell Metab.8, 347.
Milne, J.C., et al. 2007. Nature450, 712.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

188.6 °F

flash_point_c

87 °C

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全球贸易项目编号

货号	GTIN
5307480001	04055977242959

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