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Merck
CN

5.31371

S1P Receptor 2 Agonist, CYM-5520

别名:

S1P Receptor 2 Agonist, CYM-5520, S1PR2 Agonist, CYM-5520, Sphingosine-1-Phosphate Receptor 2 Agonist, CYM 5520, EDG5 Agonist

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关于此项目

经验公式（希尔记法）:
C21H19N3O2
化学文摘社编号:
1449747-00-5
分子量:
345.39
MDL number:
MFCD28100815
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

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assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

Primary Target
S1PR2
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. Does not affect the activity of S1PR1, 3, and 5 and the activity of 29 other receptors and transports in any significant manner. Acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Other Notes

Satsu, H., et al. 2013. Bioorg. Med. Chem.21, 5373.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Hideo Satsu et al.
Bioorganic & medicinal chemistry, 21(17), 5373-5382 (2013-07-16)
Molecular probe tool compounds for the Sphingosine 1-phosphate receptor 2 (S1PR2) are important for investigating the multiple biological processes in which the S1PR2 receptor has been implicated. Amongst these are NF-κB-mediated tumor cell survival and fibroblast chemotaxis to fibronectin. Here

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