Apoptosis Activator IX, DPP-23

A cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Cell permeable: yes

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Shin, Y.S., et al. 2014. Clin. Cancer Res.20, in press.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)