Asparagine Endopeptidase Inhibitor, AENK

An amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Primary Target
AEP

Reversible: yes

Packaged under inert gas

Supplied as a TFA salt.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Fmoc-Ala-Glu-Asn-Lys-NH2

Zhang, Z., et al. 1999. Nat. Med.20, 1254.
Monoury, B., et al. 1998. Nat.396, 695.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)