538904
Prostaglandin E2
>98% (HPLC), MAP kinase inhibitor, solid
别名:
Prostaglandin E2, PGE2
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关于此项目
经验公式（希尔记法）:
C20H32O5
化学文摘社编号:
分子量:
352.47
UNSPSC Code:
12352211
NACRES:
NA.77
MDL number:
产品名称
Prostaglandin E2, Involved in vasodilator actions of kinins such as bradykinin.
SMILES string
OC1C(C(C(=O)C1)C\C=C\CCCC(=O)O)\C=C\C(O)CCCCC
InChI
1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+
InChI key
XEYBRNLFEZDVAW-RTYMFESYSA-N
description
Merck USA index - 14, 7877
assay
>98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to light yellow
solubility
acetone: soluble
ethanol: soluble
ethyl acetate: soluble
methanol: soluble
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Involved in vasodilator actions of kinins such as bradykinin
Involved in vasodilator actions of kinins such as bradykinin
Product does not compete with ATP.
Reversible: no
Target IC50: 25-50 µM inhibiting MAP kinase in rat mesangial cells
Disclaimer
Toxicity: Harmful (C)
General description
Involved in vasodilator actions of kinins such as bradykinin. Inhibits MAP kinase in rat mesangial cells (IC50 = 25-50 µM). Regulates the activity of adenylate cyclase via G-protein coupled receptors.
Other Notes
Li, X., et al. 1995. Am. J. Physiol.269, C986.
Kessler, W., et al. 1992. Exp. Brain Res.91, 467.
Kessler, W., et al. 1992. Exp. Brain Res.91, 467.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Arpan Acharya et al.
Journal of virology (2020-12-18)
HIV persists in cellular reservoirs despite effective combined antiretroviral therapy (cART) and there is viremia flare up upon therapy interruption. Opioids modulate the immune system and suppress antiviral gene responses, which significantly impact people living with HIV (PLWH). However, the
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