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538925

Prostaglandin I₂, Sodium Salt

Name: Prostaglandin I<sub>2</sub>, Sodium Salt
Brand: MM

Potent vasodilatory prostaglandin produced by the endothelium.

别名:

Prostaglandin I₂, Sodium Salt, PGI₂, Prostacyclin

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₁O₅ · Na

化学文摘社编号:

61849-14-7

分子量:

374.45

UNSPSC Code:

12352211

Assay:

≥98% (HPLC)

Form:

crystalline solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: soluble

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8-;/t14-,16+,17+,18+,19-;/m0./s1

InChI key

LMHIPJMTZHDKEW-XQYLJSSYSA-M

说明

General description

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Induces vasodilation

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.

Other Notes

Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res.15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev.30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins15, 943.
Tateson, J.E., et al. 1977. Prostaglandins13, 389.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c