质量水平
方案
≥90% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
储存温度
−20°C
一般描述
Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκBα degradation, thereby interfering with induction of iNOS in macrophages.
生化/生理作用
Primary Target
chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
Product does not compete with ATP.
包装
Packaged under inert gas
外形
A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539160) in DMSO.
制备说明
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem.63, 1578.
Traenckner, E.B., et al. 1994. EMBO J.13, 5433."
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem.63, 1578.
Traenckner, E.B., et al. 1994. EMBO J.13, 5433."
Z-Ile-Glu(OtBu)-Ala-Leu-CHO
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
188.6 °F - (refers to pure substance)
闪点(°C)
87 °C - (refers to pure substance)
法规信息
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