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539162

Proteasome Inhibitor II

Name: Proteasome Inhibitor II
Brand: MM

The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

Proteasome Inhibitor II, (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO

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关于此项目

经验公式（希尔记法）:

C₂₉H₃₉N₃O₅

分子量:

509.64

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Quality level:

100

Storage condition:

OK to freeze, desiccated

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属性

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

说明

General description

A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; K_i = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MPC

Product does not compete with ATP.

Reversible: yes

Target K_i: 460 nM against the pituitary multicatalytic proteinase complex (MPC)

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.

Other Notes

Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.

Z-Leu-Leu-Phe-CHO

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c