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539209

Protein Arginine N-Methyltransferase Inhibitor, AMI-1

Name: Protein Arginine N-Methyltransferase Inhibitor, AMI-1
Brand: MM

The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

Protein Arginine N-Methyltransferase Inhibitor, AMI-1, PRMT Inhibitor I

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关于此项目

经验公式（希尔记法）:

C₂₁H₁₂N₂Na₄O₉S₂

分子量:

592.42

NACRES:

NA.77

UNSPSC Code:

12352202

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

说明

General description

A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC₅₀ = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC₅₀ = 5 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Protein arginine N-methyltransferases (PRMTs)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c