539209
Protein Arginine N-Methyltransferase Inhibitor, AMI-1
The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Protein Arginine N-Methyltransferase Inhibitor, AMI-1, PRMT Inhibitor I
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Protein arginine N-methyltransferases (PRMTs)
Protein arginine N-methyltransferases (PRMTs)
Product does not compete with ATP.
Reversible: no
Target IC50: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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