539211
Protein Methyltransferase Inhibitor, AMI-5
The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Protein Methyltransferase Inhibitor, AMI-5, Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
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关于此项目
经验公式（希尔记法）:
C29H6Br4Na2O5 · 3H2O
化学文摘社编号:
分子量:
854.00
UNSPSC Code:
12171500
NACRES:
NA.54
MDL number:
SMILES string
[Na+].[Na+].Brc1c2[o][c]3[c](c(c2cc([c]1=O)Br)c4c(cccc4)C(=O)[O-])=CC(=C(C=3Br)[O-])Br
InChI
1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChI key
SEACYXSIPDVVMV-UHFFFAOYSA-L
assay
≥90%
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
red-brown
solubility
water: 50 mg/mL
shipped in
ambient
Quality Level
General description
A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
Packaging
Packaged under inert gas
Other Notes
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
flash_point_f
376.9 °F - Pensky-Martens closed cup
flash_point_c
191.6 °C - Pensky-Martens closed cup
Fabian Wohlfromm et al.
Oncogene, 43(25), 1955-1971 (2024-05-11)
Procaspase-8 is a key mediator of death receptor (DR)-mediated pathways. Recently, the role of post-translational modifications (PTMs) of procaspase-8 in controlling cell death has received increasing attention. Here, using mass spectrometry screening, pharmacological inhibition and biochemical assays, we show that
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