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About This Item
经验公式（希尔记法）:
C29H6Br4Na2O5 · 3H2O
CAS Number:
分子量:
854.00
MDL编号:
UNSPSC代码:
12171500
NACRES:
NA.54
质量水平
方案
≥90%
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
red-brown
溶解性
water: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[Na+].[Na+].Brc1c2[o][c]3[c](c(c2cc([c]1=O)Br)c4c(cccc4)C(=O)[O-])=CC(=C(C=3Br)[O-])Br
InChI
1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChI key
SEACYXSIPDVVMV-UHFFFAOYSA-L
一般描述
A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
包装
Packaged under inert gas
其他说明
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
376.9 °F - Pensky-Martens closed cup
闪点(°C)
191.6 °C - Pensky-Martens closed cup
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