539690
Protein Synthesis Initiation Inhibitor, NSC 119889
The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5′-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Protein Synthesis Initiation Inhibitor, NSC 119889, 3,4,5,6-Tetrabromofluorescein
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light brown
solubility
DMSO: 200 mg/mL, methanol: soluble
shipped in
ambient
Quality Level
General description
A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
human arginine methyl transferase
human arginine methyl transferase
Product does not compete with ATP.
Reversible: no
Target IC50: 1.41 µM against human arginine methyl transferase
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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