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539690

Protein Synthesis Initiation Inhibitor, NSC 119889

Name: Protein Synthesis Initiation Inhibitor, NSC 119889
Brand: MM

The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5′-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

Protein Synthesis Initiation Inhibitor, NSC 119889, 3,4,5,6-Tetrabromofluorescein

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关于此项目

经验公式（希尔记法）:

C₂₀H₈Br₄O₅

分子量:

647.89

NACRES:

NA.77

UNSPSC Code:

12352202

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

light brown

solubility

DMSO: 200 mg/mL, methanol: soluble

shipped in

ambient

storage temp.

2-8°C

说明

General description

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
human arginine methyl transferase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.41 µM against human arginine methyl transferase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c