540500
Purvalanol A
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.
别名:
Purvalanol A, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
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关于此项目
经验公式（希尔记法）:
C19H25ClN6O
化学文摘社编号:
分子量:
388.89
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C
InChI
1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChI key
PMXCMJLOPOFPBT-HNNXBMFYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
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General description
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2-cyclin B; IC50 = 70 nM for Cdk2-cyclin A; IC50 = 35 nM for Cdk2-cyclin E; and IC50 = 75 nM for Cdk5-p35).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Cdc2/cyclin B
Cdc2/cyclin B
Product does not compete with ATP.
Reversible: yes
Target IC50: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35
Packaging
Packaged under inert gas
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Gray, N.S., et al. 1998. Science 281, 533.
Legal Information
Sold under license of U.S. Patents 6,617,331 and 6,803,371.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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