548000
1-吡咯烷硫代羧酸，胺盐
Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.
别名:
1-吡咯烷硫代羧酸，胺盐, APDC，吡咯烷二硫代甲酸铵盐，PDTC，NH₄
质量水平
方案
≥98% (titration)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 1 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[S-]C(=S)N1CCCC1.[N+H4]
InChI
1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChI key
MDDIUTVUBYEEEM-UHFFFAOYSA-N
相关类别
一般描述
细胞可渗透。抑制大鼠肺泡巨噬细胞一氧化氮合酶活性的诱导。防止人HL-60细胞和胸腺细胞凋亡，但诱导人和大鼠平滑肌细胞凋亡。抑制NF-κB的活化和HIV在淋巴细胞中的复制。
生化/生理作用
主要靶标
大鼠肺泡巨噬细胞一氧化氮合酶活性的诱导
大鼠肺泡巨噬细胞一氧化氮合酶活性的诱导
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
制备说明
复溶后，等分并冷冻保存（-20°C）。贮备水溶液在-20°C下可稳定保存长达3个月。
来自目录：
描述字段-添加“细胞渗透性”
来自目录：
描述字段-添加“细胞渗透性”
其他说明
Tsai, J.C., et al. 1996.J. Biol. Chem.271, 3667.
Pan, Z., et al. 1995.J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994.Biochem.Pharmacol.48, 1883.
Sherman, M.P., et al. 1993.Biochem.Biophys.Res. Commun.191, 1301.
Schreck, R., et al. 1992.J. Exp.Med.175, 1181.
Pan, Z., et al. 1995.J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994.Biochem.Pharmacol.48, 1883.
Sherman, M.P., et al. 1993.Biochem.Biophys.Res. Commun.191, 1301.
Schreck, R., et al. 1992.J. Exp.Med.175, 1181.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：刺激性（B）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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