548000
1-吡咯烷硫代羧酸，胺盐
Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.
别名:
1-吡咯烷硫代羧酸，胺盐, APDC，吡咯烷二硫代甲酸铵盐，PDTC，NH₄
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C5H12N2S2
化学文摘社编号:
分子量:
164.29
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
Assay:
≥98% (titration)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Segment
assay
≥98% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[S-]C(=S)N1CCCC1.[N+H4]
InChI
1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChI key
MDDIUTVUBYEEEM-UHFFFAOYSA-N
General description
细胞可渗透。抑制大鼠肺泡巨噬细胞一氧化氮合酶活性的诱导。防止人HL-60细胞和胸腺细胞凋亡，但诱导人和大鼠平滑肌细胞凋亡。抑制NF-κB的活化和HIV在淋巴细胞中的复制。
Biochem/physiol Actions
主要靶标
大鼠肺泡巨噬细胞一氧化氮合酶活性的诱导
大鼠肺泡巨噬细胞一氧化氮合酶活性的诱导
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备水溶液在-20°C下可稳定保存长达3个月。
来自目录：
描述字段-添加“细胞渗透性”
来自目录：
描述字段-添加“细胞渗透性”
Other Notes
Tsai, J.C., et al. 1996.J. Biol. Chem.271, 3667.
Pan, Z., et al. 1995.J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994.Biochem.Pharmacol.48, 1883.
Sherman, M.P., et al. 1993.Biochem.Biophys.Res. Commun.191, 1301.
Schreck, R., et al. 1992.J. Exp.Med.175, 1181.
Pan, Z., et al. 1995.J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994.Biochem.Pharmacol.48, 1883.
Sherman, M.P., et al. 1993.Biochem.Biophys.Res. Commun.191, 1301.
Schreck, R., et al. 1992.J. Exp.Med.175, 1181.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable