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Merck
CN

551476

Q-VD-OPh，非-O-甲基化

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®

别名:

InSolution Q-VD-OPh，非O-甲基化, N-(2-喹啉基)缬氨酰-天冬氨酰-(2,6-二氟苯氧基)甲基酮

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关于此项目

经验公式（希尔记法）:
C26H25F2N3O6
分子量:
513.49
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light

主要文件

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产品名称

Q-VD-OPh，非-O-甲基化, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases

assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：对于半胱天冬酶-1、-8、-9和-3分别为50、100、430和<25 nM
主要靶标
半胱天冬酶-1

Disclaimer

毒性：刺激性（B）

General description

一种细胞渗透性、不可逆、广谱的半胱天冬酶抑制剂（对于半胱天冬酶-1、-8、-9和-3的IC50分别为50、100、430和<25 nM），对所有主要的半胱天冬酶介导的细胞凋亡途径具有有效的抗凋亡特性。即使在极高浓度下也不会表现出细胞毒性作用。显示可减少缺血性脑损伤和中风诱导的胸腺和脾脏中程序性细胞死亡。

Other Notes

Braun, J.S., et al. 2007.Exp.Neurol.206, 183.
Caserta, T.M., et al. 2003.Apoptosis8, 345.
Rebbaa, A., et al. 2003.Oncogene22, 2805.
Q-Val-Asp-CH₂-OPh

Packaging

用惰性气体包装

Physical form

以10mM（1mg/195µL）的DMSO溶液的形式提供。

Preparation Note

初次融化后，等分并冷冻（-20°C）。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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Joshua D Bryant et al.
Current protocols, 2(2), e372-e372 (2022-02-18)
Mitochondria have emerged as key drivers of mammalian innate immune responses, functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches required for phagocyte activation. Mitochondria also contain damage-associated molecular patterns (DAMPs), molecules that share similarity with pathogen-associated molecular
Javier Chicote et al.
Frontiers in pharmacology, 11, 580343-580343 (2020-11-13)
Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. Constitutive, or basal autophagy, unfolds under nutrient-replete conditions to maintain the cellular homeostasis.
Yuanjiu Lei et al.
Cell, 186(14), 3013-3032 (2023-06-24)
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic acid sensors remain poorly defined. Here, we show that mitochondrial genome instability promotes
Sara H Small et al.
Science signaling, 14(714), eaba2611-eaba2611 (2021-12-22)
Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and

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