551590
Quercetagetin
A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM).
别名:
Quercetagetin, 3,3ʹ,4ʹ,5,6,7-Hexahydroxyflavone
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow to yellow-green
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
InChI key
ZVOLCUVKHLEPEV-UHFFFAOYSA-N
一般描述
A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC50 = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC50 = 3.45 µM), and little activity toward c-Abl even at concentrations as high as 200 µM. Inhibits cellular BAD phosphorylation (IC50 = 5.5 µM) and induces growth arrest (ED50 = 3.8 µM) in PIM1-expressing RWPE2 cells.
生化/生理作用
Cell permeable: yes
Primary Target
PIM1 kinase
PIM1 kinase
Product competes with ATP.
Reversible: yes
Target IC50: 340 nM against PIM1 kinase
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Holder, S., et al. 2007. Mol. Cancer Ther.6, 163.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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