551590
Quercetagetin
A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM).
别名:
Quercetagetin, 3,3ʹ,4ʹ,5,6,7-Hexahydroxyflavone
InChI
1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
InChI key
ZVOLCUVKHLEPEV-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow to yellow-green
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
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General description
A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC50 = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC50 = 3.45 µM), and little activity toward c-Abl even at concentrations as high as 200 µM. Inhibits cellular BAD phosphorylation (IC50 = 5.5 µM) and induces growth arrest (ED50 = 3.8 µM) in PIM1-expressing RWPE2 cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PIM1 kinase
PIM1 kinase
Product competes with ATP.
Reversible: yes
Target IC50: 340 nM against PIM1 kinase
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Holder, S., et al. 2007. Mol. Cancer Ther.6, 163.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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